STUDIES ON AIRWAY HYPERRESPONSIVENESS BY THE ASTOGRAPH^[○!R] METHOD IN ASTHMATICS AND YOUNG ADULT NON-ASTHMATIC ASYMPTOMATICS

DOI Web Site 1 Citations 37 References
  • Fukui Yoshinobu
    First Department of Medicine, Hokkaido University School of Medicine
  • Yamaguchi Etsuro
    First Department of Medicine, Hokkaido University School of Medicine
  • Hizawa Nobuyuki
    First Department of Medicine, Hokkaido University School of Medicine
  • Maeda Yukiko
    First Department of Medicine, Hokkaido University School of Medicine
  • Takahashi Daisuke
    First Department of Medicine, Hokkaido University School of Medicine
  • Konno Satoshi
    First Department of Medicine, Hokkaido University School of Medicine
  • Kobayashi Motoko
    First Department of Medicine, Hokkaido University School of Medicine
  • Hosokawa Takeshi
    First Department of Medicine, Hokkaido University School of Medicine
  • Jinushi Eisei
    First Department of Medicine, Hokkaido University School of Medicine
  • Takamura Kei
    First Department of Medicine, Hokkaido University School of Medicine
  • Nasuhara Yasuyuki
    First Department of Medicine, Hokkaido University School of Medicine
  • Nishimura Masaharu
    First Department of Medicine, Hokkaido University School of Medicine

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Other Title
  • 気管支喘息患者と若年成人無症候者におけるアストグラフ^[○!R]法による気道過敏性の検討
  • 気管支喘息患者と若年成人無症候者におけるアストグラフ法による気道過敏性の検討
  • キカンシ ゼンソク カンジャ ト ジャクネン セイジン ムショウコウシャ ニ オケル アストグラフホウ ニ ヨル キドウ カビンセイ ノ ケントウ

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Abstract

We investigated airway hyperresponsiveness (AHR) by the continuous inhalation method using an Astograph^[○!R] in 105 asthmatics and 141 non-asthmatic asymptomatics. The range of Dmin (1 U = one minute inhalation of 1mg/ml of methacholine) of asthmatics was 0.001 to 28.70 U, and that of adjusted Dmin of non-asthmatic asymptomatics was 0.28 to 190 U ; thus, an apparent overlap was recognized in the distributions of Dmin. Ninety-five percent of asthmatics had a Dmin lower than 7 U, and 95% of non-asthmatic asymptomatics had a Dmin higher than 0.9 U. Presuming that almost all asthmatics had AHR, it was inferred that nearly half of non-asthmatic asymptomatics had AHR, too. Comparison with previous reports suggests that AHR in healthy people may be increasing generally. When Dmin is determined to be >7 U by the Astograph^[○!R] method, it is likely that the patient does not have asthma. When a patient has a Dmin<0.9 U, it is highly probable that the patient has asthma.

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