TWO CASES OF APIACEAE SPICE ALLERGY

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  • セリ科スパイスアレルギーの2例
  • 症例報告 セリ科スパイスアレルギーの2例
  • ショウレイ ホウコク セリカ スパイス アレルギー ノ 2レイ

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Background: Many cases of spice allergy have been reported especially from Scandinavian countries, but in contrast there are few reports in Japan. This time we experienced two cases of apiaceae spice allergy and practiced some kinds of examinations. We report here these two cases with the consideration concerning mechanizm of spice allergy. Methods and Subjects: We practiced 1) specific IgE of pollens and foods, 2) prick tests of spices and apiaceae vesitables, 3) immunoblot of spices, against two cases suspected spice allergy from their clinical courses. Clinically Case 1 32y.o. male had been no history of pollinosis, in contrast Case 2 46y.o. female had been suffered from pollinosis during spring and autumn seasons. Results: In Case 1 the scores of specific IgE of pollens were almost negative and immunoblot examination of spices revealed positive reaction at the site of 10〜12kDa and 60kDa. In Case 2 the scores of specific IgE of pollens were positive in many species and immunoblot examination of spices reacted positively at the site of 14kDa and 60kDa. Both of them showed positive reactions against many kinds of apiaceae spices in prick tests, so we diagnosed them as apiaceae spice allergy. Conclusion: According to these results we suspected Case 1 as class 1 allergy induced by the sensitization of spices themselvs and Case 2 as class 2 allergy caused by the cross reactions with pollinosis. So there may be some different mechanizms in the occurrence of spice allergy. In the future the occurrence of spice allergy will be supposed to increase and it will be necessary for us to pay much more attention to spice allergy even in Japan.

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