A CASE OF MINOCYCLINE-INDUCED PNEUMONITIS WITH BILATERAL PLEURAL EFFUSION

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  • Arai Satoko
    Department of Respiratory Medicine, International Medical Center of Japan
  • Shinohara Yuka
    Department of Respiratory Medicine, International Medical Center of Japan
  • Kato Yasuyuki
    Department of Respiratory Medicine, International Medical Center of Japan:Disease Control & Prevention Center, International Medical Center of Japan
  • Hirano Satoshi
    Department of Respiratory Medicine, International Medical Center of Japan
  • Yoshizawa Atsuto
    Department of Respiratory Medicine, International Medical Center of Japan
  • Hojyo Masaaki
    Department of Respiratory Medicine, International Medical Center of Japan
  • Kobayashi Nobuyuki
    Department of Respiratory Medicine, International Medical Center of Japan
  • Sugiyama Haruhito
    Department of Respiratory Medicine, International Medical Center of Japan
  • Kudo Koichiro
    Disease Control & Prevention Center, International Medical Center of Japan

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Other Title
  • 両側胸水を伴ったミノサイクリンによる薬剤性肺炎の1例
  • 症例報告 両側胸水を伴ったミノサイクリンによる薬剤性肺炎の1例
  • ショウレイ ホウコク リョウガワ キョウスイ オ トモナッタ ミノサイクリン ニ ヨル ヤクザイセイ ハイエン ノ 1レイ

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Abstract

A 51-year-old man was admitted to our hospital with fever, dry cough and dyspnea. He had taken minocycline for 11 days because of urinary tract infection. Chest X-ray on admission showed diffuse reticular shadows in bilateral lung fields with bilateral pleural effusion. Cessation of minocycline led to spontaneous improvement of symptoms and radiographic findings. The lymphocyte stimulation test for minocycline with peripheral blood and pleural effusion were negative. After provocation test with minocycline, he developed fever and dry cough and bilateral ground glass opacity appeared on his chest X-ray. He was diagnosed as minocycline-induced pneumonitis and recovered rapidly following corticosteroid therapy.

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