THE AGE OF ONSET OF ADULT-ONSET ASTHMA IS INCREASING IN JAPANESE WOMEN

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  • Tsukioka Kazuharu
    Niigata Allergic Disease Research Institute:Tsukioka Clinic for Internal Medicine
  • Toyabe Shin-ichi
    Department of Patient Safety, Niigata University Medical and Dental Hospital
  • Kogusuri Yuko
    Division of Information Science and Biostatistics, Department of Medical Informatics and Pharmaceutics, Niigata University Graduate School of Medical and Dental Sciences
  • Akazawa Kouhei
    Department of Medical Informatics, Niigata University Medical and Dental Hospital, Niigata University

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  • 成人発症喘息の女性の発症年齢は上昇傾向にある
  • セイジン ハッショウ ゼンソク ノ ジョセイ ノ ハッショウ ネンレイ ワ ジョウショウ ケイコウ ニ アル

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Abstract

Background: Although the age of onset of childhood bronchial asthma is known to be decreasing, the age of onset of adult-onset asthma has yet to be comprehensively investigated. Methods: We examined the records of 5067 asthma patients (2047 males) aged 16 years or older who visited our clinic during a recent 9-year period (1997 through 2005). The definition of adult-onset asthma (ie, new-onset persistent asthma developing at 20 years or older) was based on the Akiyama classification. We analyzed the associations between a number of putative risk factors and age of onset. Results: Although the age of onset of adult-onset asthma did not change significantly in males (43.0±13.8 [mean±SD] years in 1997 vs 44.5±15.2 years in 2005), a significant increase was observed in females (40.6±15.3 years in 1997 vs 43.5±16.1 years in 2005, p<0.001). Conclusion: Our data indicate that, during a recent 9-year period, the age of onset of adult-onset asthma appears to be increasing in females, most likely because the numbers of female asthmatics who smoke, have a high total serum IgE level (IgE&ge;300IU/ml), have a high mite-specific IgE antibody score (RAST score&ge;2), and have complications from or a past history of allergic rhinitis have declined.

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