LIVER DAMAGE IN TREATMENT OF LATENT TUBERCULOUS INFECTION BY ISONIAZID

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  • イソニアジドによる潜在性結核治療の肝障害
  • イソニアジド ニ ヨル センザイセイ ケッカク チリョウ ノ カン ショウガイ

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Abstract

[Purpose] To study the frequency and degree of liver damage as adverse effect of isoniazid (INH) preventive therapy in Japanese people.<BR>[Object and Metho d] Chart review of Japanese persons who started isoniazid preventive chemotherapy in the two clinics in Tokyo, from 2003/1/1 to 2004/12/31.<BR>[Result] There were 77 9 cases who did not transiently or completely stop INH preventive therapy because of adverse effect, and 26 cases who stopped INH transiently or completely because of liver damage as adverse effect (total 805 cases). In 371 cases, of those 779 cases, AST (asparate aminotransferase) and ALT (alanine aminotransferase) was measured after starting INH at least once. In 14. 9% (59/397) of these 391 cases ( =371 + 26), liver damage as adverse effect was found. In 1. 51 % (6/397), liver damage with AST and/or ALT higher than 400 11U/L was found. Clinical hepatitis, associated with clinical symptom of hepatitis, was seen in 0. 37% (3/805). Hepatitis with liver failure was seen in 0. 12%. There was no death due to liver damage.<BR>[Conclusion] Li ver damage as adverse effect of isoniazid (INH) preventive therapy in Japanese people is not rare.

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