The Effectiveness of Steroid as Adjunctive Therapy in the Management of Two Patients with Febrile Reaction Due to Antituberculous Drugs.

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  • 抗結核薬による熱発に対しステロイド併用し治療可能となった２症例
  • ショウレイ ホウコク コウケッカクヤク ニ ヨル ネッパツ ニ タイシ ステロイド ヘイヨウ シ チリョウ カノウ ト ナッタ 2 ショウレイ

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Antituberculous treatment could be continued by using steroid as adjunctive therapy in two patients showing feabrile reaction to antituberculous drugs in spite of desensitization therapy.<BR>Case 1 (39-year-old man) was admitted to our hospital with positive sputum-smear and bilateral cavitary tuberculosis (b II 2) on chest X-ray. He showed fever of 38-39°C after 8 days of HREZ treatment. Desensitization therapy of RFP with the combined use of prednisolone was enforced, since the exothermic reaction continued in spite of stopping the 4 medicines, and the treatment became possible. Case 2 (40-year-old woman) was admitted with positive sputum-smear and bilateral cavitary tuberculosis (b II 2) on chest Xray. The administration of drugs was stopped as temperature rose to 38-39 t after 12 days of HREZ treatment. Though the DLST of INH was positive, the treatment with INH became possible by the combined use of PSL.

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