結核化学療法における維持期週２回間欠療法の効果と副作用

DOI Web Site 被引用文献5件 参考文献19件

書誌事項

タイトル別名
  • TWICE-WEEKLY INTERMITTENT CHEMOTHERAPY DURING THE MAINTENANCE PHASE OF THE SHORT-COURSE TREATMENT FOR NEW PATIENTS WITH PULMONARY TUBERCULOSIS
  • ケッカク カガク リョウホウ ニ オケル イジキ シュウ 2カイ カンケツ リョウホウ ノ コウカ ト フクサヨウ

この論文をさがす

抄録

[Background and Objective] Various types of intermittent chemotherapy regimens have been applied for the treatment of tuberculosis worldwide, but, in Japan, any type of intermittent treatment has not been adopted currently as the standard regimens for the treatment of tuberculosis. Intermittent regimens have a great advantage to facilitate directly observed therapy (DOT). To introduce DOT more extensively in Japan, we conducted the present clinical trial to assess the effectiveness and safety of intermittent chemotherapy.<BR>[Patients and Methods] This is a non-randomized trial to compare twice-weekly intermittent therapy under DOT with daily therapy by self-administration. Newly diagnosed patients with pulmonary tuberculosis who completed the initial intensified phase of 2 months with 4 drugs were enrolled. Supervision of drug administration was carried out by the pharmacists who cooperated to the study (Pharmacy DOT).<BR>[Results] Total 385 patients were enrolled in this trial, of which 135 patients were treated by twice-weekly intermittent maintenance chemotherapy under the supervision by pharmacists and remaining 250 patients were treated by daily maintenance chemotherapy without supervision (self-administration). Treatment success-rates were 97. 6% for intermittent treatment group and 95. 6% for daily treatment group. Relapse rates after the completion of the treatment course were 3. 73/ 100 person-year and 1. 76/100 person-year, respectively. The difference between the two groups was not statistically significant. Adverse events required the modification of treatment schedule occurred only in 0. 2% of the intermittently treated patients.<BR>[Con clusions] After the successful completion of the initial intensified phase of tuberculosis chemotherapy, twice-weekly intermittent chemotherapy during the maintenance phase under the supervision by pharmacist is as effective and safe as the daily therapy, and is conveniently accepted by the patients. The pharmacy DOT with the intermittent therapy during maintenance phase adopted in this trial, should be widely introduced in Japan.

収録刊行物

  • 結核

    結核 81 (5), 363-369, 2006

    一般社団法人 日本結核病学会

被引用文献 (5)*注記

もっと見る

参考文献 (19)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ