LIVER DYSFUNCTION INDUCED BY RIFAMPICIN
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- KUTSUKAKE Fumiko
- From the National Hiroshima Chest Hospital
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- MURAKAMI Tae
- From the National Hiroshima Chest Hospital
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- SASAKI Yoriko
- From the National Hiroshima Chest Hospital
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- MITANI Yoshio
- From the National Hiroshima Chest Hospital
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- KAMADA Tohru
- From the National Hiroshima Chest Hospital
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- SHIGETO Norikazu
- From the National Hiroshima Chest Hospital
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- YOSHIOKA Hiroko
- From the National Hiroshima Chest Hospital
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- SEWAKE Norio
- From the National Hiroshima Chest Hospital
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- FUKUHARA Noriaki
- From the National Hiroshima Chest Hospital
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- SHIBATA Yoshihiko
- From the National Hiroshima Chest Hospital
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- SHIGETO Eriko
- From the National Hiroshima Chest Hospital
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- TANAKA Kuniko
- From the National Hiroshima Chest Hospital
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- KADOSAWA Katsutoshi
- From the National Hiroshima Chest Hospital
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- KOU Eihaku
- From the National Hiroshima Chest Hospital
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- MOCHIZUKI Koji
- From the National Hiroshima Chest Hospital
Bibliographic Information
- Other Title
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- RFPによる肝障害
- RFP ニヨル カン ショウガイ
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Abstract
Rifampicin (RFP)-induced liver dysfunction during the treatment for tuberculosis was discussed.<BR>Incidence of RFP-induced liver dysfunction was 11.1 % (151 cases) among 1, 359 cases treatedwith RFP-containing regimens.<BR>Many of the RFP-induced liver dysfunction were observed in the early stage of chemotherapy, and the elevation of serum transaminases (s-GOT and s-GPT) was mild in the majority of cases. Asthe recovery was retarded among cases with s-transaminases above 100 K-U than cases below 100, the former RFP should be discontinued in the former until the restoration of liver dysfunction.<BR>Attention should be payed to the cases with elevated s-transaminases combined with abnormalitiesof other laboratory data such as ZnTT, history of other liver dysfunction, diabetes mellitus or habitualdrinkings, as the recovery of liver dysfunction is retarded in such cases.<BR>The liver dysfunction as one of the side-effects should be given proper attention in the treatmentfor tuberculosis, considering long-term benefit of patients.
Journal
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- Kekkaku(Tuberculosis)
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Kekkaku(Tuberculosis) 57 (4), 257-261, 1982
JAPANESE SOCIETY FOR TUBERCULOSIS
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Details 詳細情報について
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- CRID
- 1390282679976904832
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- NII Article ID
- 130001416751
- 10004929971
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- NII Book ID
- AN00073442
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- ISSN
- 18842410
- 00229776
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- NDL BIB ID
- 2487696
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- PubMed
- 7109426
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed