細菌感染とＴｏｌｌ‐ｌｉｋｅ　ｒｅｃｅｐｔｏｒｓ

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  • 審良 静男
    大阪大学微生物病研究所癌抑制遺伝子研究分野

書誌事項

タイトル別名
  • Bacterial Infections and Toll-like Receptors.
  • ダイ76カイ ソウカイ キョウイク コウエン サイキン カンセン ト Toll-like receptors
  • BACTERIAL INFECTIONS AND TOLL-LIKE RECEPTORS
  • 細菌感染とToll-like receptors

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説明

Toll-like receptors are type-1 transmembrane receptors involved in microbial recognition. TLR4 has been shown to function as the lipopolysaccharide signaling receptor, while TLR2 recognizes peptidoglycans from Gram-positive bacteria, and lipoproteins. TLR9 is involved in the recognition of bacterial DNA (CpG DNA). Although various microbial cell wall components are recognized by different receptors, all of these responses are abrogated in MyD88-deficient cells. These results show that different TLRs recognize different microbial cell wall components, and that MyD88 is an essential signaling molecule shared among interleukin-1 receptor/Toll family members. However, in LPS signaling MyD 88-independent pathway is present in addition to MyD 88-dependent pathway.

収録刊行物

  • 結核

    結核 76 (8), 593-600, 2001

    一般社団法人 日本結核病学会

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