看護学生における繰り返しツベルクリン反応　　在学３年間の変動

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書誌事項

タイトル別名
  • Repeated Tuberculin Skin Tests in Nurse Students. Observation for 3 Years.
  • カンゴ ガクセイ ニ オケル クリカエシ ツベルクリン ハンノウ : ザイガク 3ネンカン ノ ヘンドウ
  • Observation for 3 Years
  • 在学3年間の変動

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抄録

In Japan, two-step tuberculin skin test (two-step TST) is recommended for health care workers (HCWs) if the diameter of erythema in the first test is less than 30 mm, and to detect new infection if there is 10 mm or more increase from the base-line diameter. We observed TST in nurse students from the entrance to the graduation for 3 years, and analyzed the change of TST reaction to discuss the usefulness of two-step TST and the criteria for detecting new tuberculous infection among BCG vaccinated HCWs. Mean ± S.D. (mm) in erythema and induration in each occasion were: in a group with single TST at entrance (T1) and before graduation (TG) (n=99, group I); T1=19.8 ± 11.3, TG=23.6 ± 14.3 for erythema and Ti=12.5 ± 5.3, TG=13.8 ± 5.0 for induration: in a group with two-step TST at entrance (T1 and T2) (n=40, group II); T1=11.9 ± 7.8, T2=20.4± 10.6, TG=22.1 ± 13.5 for erythema and T1=8.6±6.1, T2=12.0± 5.1, TG=13.4± 5.4 for induration: in a group BCG vaccinated after single negative TST (less than 10 mm of erythema and/or less than 5 mm of induration) (n=12, group I-B); T1=4.0 ± 3.5, TB=19.8 ±5.8, TG=16.3 ± 7.6 for erythema and T1=0.5 ± 1.5, TB=14.1 ± 3.7, TG=11.9 ± 4.4 for induration: in a group BCG vaccinated after two negative TST (n=10, group II-B); T1=3.6±3.1, T2=6.2±2.4, TB=23.9±8.5, TG=14.1±6.9 for erythema and T1=1.7 ± 2.7, T2=3.2 ± 1.8, TB=16.0 ± 3.2, TG=7.5 ± 7.8 for induration. One student in the group II was diagnosed as tuberculosis before the graduation. If we exclude this case form the group II, mean± S.D. (mm) of TG in group II were 20.7 ± 11.2 for erythema and 13.1 ± 5.0 for induration. Booster phenomenon was significant on twostep TST. There was moderate booster phenomenon even after 34 months from the previous single TST. There was also significant waning of reaction 27 to 31 months after BCG vaccination. But there were no significant waning nor booster after two-step TST.<BR>Concerning the difference between the reaction betore graduation and at entrance, mean± S.D. (mm) in erythema and induration, [TG-T1] in the group I were+3.8±11.4 and +1.6±5.8. respectively. [TG-T2or1] in the group II were +0.7 ±11.4 and ± 0.4 ± 5.6, respectively, [TG- TB] in the group I-B and II-B were-6.4 ± 9.9 and-5.0 ± 6.5. If we exclude one case who got tuberculosis from the group II, mean ± S. D. (mm) in erythema and induration of [TG- T2] in group II were-0.6 ± 8.1 and +0.2 ± 5.4, respectively.

収録刊行物

  • 結核

    結核 77 (10), 659-664, 2002

    一般社団法人 日本結核病学会

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