Differences in Effects of Sodium Fluoride and Sodium Monofluorophosphate on Acid Resistance of Enamel

  • YAMAGISHI Atsushi
    Health Care Products Research Laboratories, Kao Corporation
  • KATO Kazuo
    Department of Preventive Dentistry and Dental Public Health, School of Dentistry, Aichi-Gakuin University
  • NAKAGAKI Haruo
    Department of Preventive Dentistry and Dental Public Health, School of Dentistry, Aichi-Gakuin University

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  • 950ppmFフッ化ナトリウムおよびモノフルオロリン酸ナトリウムのエナメル質耐酸性に及ぼす影響
  • 950ppmF フッカ ナトリウム オヨビ モノフルオロリンサン ナトリウム ノ エナメルシツ タイサンセイ ニ オヨボス エイキョウ

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Abstract

Sodium fluoride (NaF) and Sodium monofluorophosphate (MFP) are the most common anticaries ingredients used in fluoride dentifrices. The purpose of this study was to investigate the differences in effects of NaF and MFP on acid resistance of enamel. In this study, we employed conditions of fluoride treatment which simulated the daily use of fluoride dentifrices. The treatment of enamel specimens was carried out in solution of 950 ppmF NaF or MFP (2 times/day, 3 min/time, for 22 days). Following fluoride treatments, specimens were immersed in demineralizing solution (pH 4.5). The changes in lesion mineral contents, ΔZ, and the lesion depth (Ld) were assessed by quantitative microradiography. Enamel specimens treated with NaF showed significantly higher acid resistance than with MFP treatment (ΔZ: NaF<MFP, Ld: NaF<MFP). After 22-day fluoride treatment, specimens were demineralized (pH 4.0) for 6 days to investigate the structure of the acid-resistant layer. Microradiography revealed large differences in acid resistance between NaF and MFP. NaF-treated enamel showed acid resistant at only a superficial area. However, MFP-treated enamel had a thick and deep acid-resistant layer. Therefore, NaF could not penetrate into the enamel, while MFP penetrated deeper. The results showed that NaF and MFP made an interesting contrast concerning the investment of acid resistance under acidic conditions.

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