副腎皮質ホルモンの急性粟粒結核症の誘発ならびに進展に及ぼす影響

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書誌事項

タイトル別名
  • EFFECT OF CORTICOSTEROID HORMONES ON INDUCTION AND DEVELOPMENT OF ACUTE MILIARY TUBERCULOSIS IN RABBITS
  • フクジン ヒシツ ホルモン ノ キュウセイ ゾクリュウ ケッカクショウ ノ ユ
  • I. Roentgenological and Histopathological Observations
  • 第1編 X線学的ならびに病理学的所見を中心として

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In view of the fact that the incidence of acute miliary tuberculosis has been noticeably increasing in recent years, the effect of corticosteroid hormones (CS) on experimental miliary tuberculosis of rabbits was studied with the object of elucidating inducing and aggravating factors for the disease. The present paper is concerned with histopathological and roentgenological investigations made on CS-treated and non-treated (control) rabbits infected with tubercle bacilli in order to ascertain the aggravating effect of CS on experimental miliary tuberculosis and to clarify partly the mechanism involved. The results obtained are summarized as follows:<BR>1. The ultrasoft X-ray image of the lungs of rabbits infected with tubercle bacilli without CS administration showed typical miliary nodular shadows distributed sparsely but evenly along the blood vessel shadows from the hilar area to the periphery. In contrast, in the CS-treated rabbits the nodular shadows were large in number and densely distributed over the whole lung field and coalesced partly with each other to form larger shadows.<BR>2. Pathomorphologically, the miliary nodules in the lungs of control rabbits tended to dis appear with the lapse of time. In contrast, the lesions in the lungs of rabbits treated with CS were characterized by delayed absorption accompanied by exudative process. The lesions were extensive and after seven weeks underwent caseous necrosis and innumerable tubercle bacilli were contained in the lesion.<BR>3. The lesions in the liver of CS-treated rabbits showed similar finding to that in the lung. The lesions in the kidney showed no definite pattern, and those in the spleen showed as a whole a marked tendency to heal spontaneously, and the effect of CS was less.<BR>4. From these results, it was suggested roentgenologically and histopathologically that the CS treatment definitely interferes with the healing process of acute miliary tuberculosis. These facts might have verified to a certain extent the relation between administration of CS and the induction and development of miliary tuberculosis.

収録刊行物

  • 結核

    結核 52 (11), 549-561, 1977

    一般社団法人 日本結核病学会

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