感染菌の増殖度と結核化学療法効果

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書誌事項

タイトル別名
  • STUDIES ON THE RELATIONSHIP BETWEEN THE PROLIFERATION RATE OF INFECTING TUBERCLE BACILLI AND THE EFFECTIVENESS OF CHEMOTHERAPY
  • カンセンキン ノ ゾウショクド ト ケッカク カガク リョウホウ コウカ 2
  • II. Observations in Various Types of Infection Experiment
  • II. 種々な感染条件における観察

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抄録

1) Isoniazid-treatment was poor in its effectiveness on tubercle bacilli of the secondary infection whose multiplication was inhibited under the pressure of acquired immunity induced by the primary infection.<BR>2) Mice were infected intravenously with tubercle bacilli preexposed in vitro to a low concentration of streptomycin (5 μg/ml). Isoniazid-treatment with 0.5 mg daily dose was less effective on these infecting bacilli than on the unexposed control bacilli.<BR>3) The multiplication of infecting tubercle bacilli was accelerated by cortisone-administration. Isoniazid-treatment was highly effective on those bacilli as revealed by remarkable reduction of viable counts in the spleen.<BR>4) From these observations it was concluded that isoniazid-treatment was more effective when infecting bacilli were more active in multiplication.

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  • 結核

    結核 52 (10), 475-479, 1977

    一般社団法人 日本結核病学会

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