Urokinase併用による肺結核化学療法の効果増強の試み

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タイトル別名
  • AN ATTEMPT TO ENHANCE THE ANTITUBERCULOUS EFFECT OF CHEMOTHERAPEUTICS BY THE COMBINED ADMINISTRATION OF UROKINASE FOR PULMONARY TUBERCULOSIS
  • Urokinase ヘイヨウ ニヨル ハイ ケッカク カガク リョウホウ ノ

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抄録

Combination therapy of antituberculous agents and urokinase (daily dose: 3, 600-6, 000u) was carried out in 13 pulmonary tuberculosis patients who showed no changes on chest roentogenogram by chemotherapy for 2 to 6 months. The following good results were obtained.<BR>Of 4 cases of CB type on roentogenogram, improvement was obtained in 3. Out of 9 with lesions of T, Kx, Ky and Kd types, 5 showed improvement, and in some cases, the improvement was obtained for 3 months after urokinase treatment. Including these cases improved later, the size of lesions finally reduced in 9 cases (69.2%) roentogenographically.<BR>Of 7 cases who were indicated pulmonary resection, the conditions were improved so markedly in 4 cases that the chest surgery was no more needed.<BR>The administration of urokinase for 1 to 1.5 months showed no effect except in one case. Our study suggests that the duration of combination therapy of urokinase and antituberculous agents must be for 3 to 6 months to obtain its clinical efficacy.<BR>No side effects due to urokinase and antituberculous drugs were observed.

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  • 結核

    結核 52 (10), 497-504, 1977

    一般社団法人 日本結核病学会

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