第53回総会特別講演

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書誌事項

タイトル別名
  • The 53rd Annual Meeting Special Lecture
  • ミコ バクテリア ト サイボウセイ メンエキ
  • II. MYCOBACTERIA AND CELLULAR IMMUNITY
  • II. ミコバクテリアと細胞性免疫

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抄録

It has been shown that mycobacterial cells including tubercle bacilli were very useful tool for the study on cellular immunology. In this review, I summarize the results of our immunological study on tubercle bacilli.<BR>1. Experimental cavity formation in rabbits. We have clearly shown that experimental tuberculous cavity was produced by the intrathoratic injection of heat-killed mycobacterial cells suspended in mineral oil. Recently it was also shown that the intrathoratic injection of my cobacterial protein antigen together with potent adjuvant substance such as BCG cell-wall skeleton emulsified in Freund's incomplete adjuvant produced experimental cavity in rabbits.<BR>2. Tuberculin active peptide (TAP). TAP purified from the defatted cells of mycobacteria and nocardia was shown to be low molecular weight (<10, 000 dalton) and stable. The specificity of TAP in skin-reaction is almost similar with that of PPDs.<BR>3. Cancer immunotherapy with BCG cell-wall skeleton (CWS).<BR>BCG-CWS was shown to have principal chemical structure of “mycolic acid-arabinogalactanmucopeptide” complex, and the adjuvant activity of BCG-CWS was examined in detail. We have also shown that oil-attached BCG-CWS had potent anti-tumor activity in transplantable tumors in syngeneic mice, rats and guinea pigs. BCG-CWS stimulated the depressed T cell function to normal level in tumor-bearing host. The incidence of carcinogenicity with chemical carcinogens in mice, rats and rabbits was inhibited by the administration of BCG-CWS. BCG-CWS is now being used as immunotherapeutic agent for the treatment of human malignant diseases especially in the patients with lung cancer and leukemia.<BR>4. Synthetic peptidoglycan subunits.<BR>The minimum adjuvant-active subunit of bacterial cell-wall was established to be N-acetyl muramyl-L-alanyl-D-isoglutamine (MDP). MDP was shown to have adjuvant activity, but no antitumor activity. 6-O-Mycoloyl-MDP showed potent adjuvant activity on cellular immune response and antitumor activity in transplantable tumor in syngeneic mice. It was also found that the immunization with DNP-6-OMycoloyl-MDP induced the IgE specific suppressor cells which did not affect on the production of IgG class antibody to DNP.

収録刊行物

  • 結核

    結核 53 (11), 551-554, 1978

    一般社団法人 日本結核病学会

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