EPIDEMIOLOGICAL AND BACTERIOLOGICAL STUDIES ON ATYPICAL MYCOBACTERIOSIS IN JAPAN

TSUKAMURA Michio, SHIMOIDE Hisao, KITA Nobuhiko, KAWAKAMI Keisi, ITO Tadao, NAKAJIMA Naoto, KONDO Hiroko, YAMAMOTO Yoshitaka, MATSUDA Noboru, TAMURA Masatoshi, YOSHIMOTO Kazuo, SHIROTA Nobumitsu, KUZE Akihiko

doi:10.11400/kekkaku1923.55.273

The prevalence rate of atypical lung mycobacteriosis was studied in patients hospitalized to thirteen participating hospitals during the period from January 1, 1971 to December 31, 1978. A total of 29, 580 patients with lung disease were hospitalized in tuberculosis departments in the above period, and, among them, 462 patients were found to be atypical lung mycobacteriosis. Screening for atypical mycobacteria was carried out using PNB medium (Ogawa egg medium containing 0.5mg/ml p-nitrobenzoic acid). Acidfast organisms isolated from sputum specimens of patients were inoculated onto the PNB medium and an Ogawa egg medium containing no agent (control), and the organisms growing on the PNB medium after incubation at 37°C for 3 weeks were sent to the Chubu Hospital and identification was made according to due schedule (Tsukamura, M.: Identification of mycobac teria, 1975). The lung atypical mycobacteriosis was diagnosed using the following criteria: (1) isolation of atypical mycobacteria belonging to the same species more than three times within the period of six months and the isolates should at least more than two times consist of more than 100 colonies (the latter was not adopted in diagnosing diseases due to M. kansasii and M. fortuitum); (2) the excretion of atypical mycobacteria into sputum should be accompanied by the appearance of clinical symtoms (appearance of cavities, etc.). The screening and the diagnosis were carried out using the same technique and the same criteria.

EPIDEMIOLOGICAL AND BACTERIOLOGICAL STUDIES ON ATYPICAL MYCOBACTERIOSIS IN JAPAN

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