COMPARATIVE STUDIES ON TUBERCULIN ACTIVITIES OF TUBERCULIN ACTIVE PEPTIDE (TAP) AND ITS DERIVATIVES FOR HUMAN BODIES

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  • ツベルクリン活性ペプチド(TAP)およびその各種誘導体のツベルクリン力価の比較
  • ツベルクリン カッセイ ペプチド TAP オヨビ ソノ カクシュ ユウドウタイ ノ ツベルクリン リキカ ノ ヒカク

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Abstract

In this report the activity of tuberculin active peptide (TAP) and its derivatives and their stability against papain digestion were tested. The object of this experiment was to obtain a more potent or more stable derivative against proteinase than TAP.<BR>TAP coupled with diazotized sulfanylic acid or diazotized ο-aminophenol and acetylateci TAP were less active than TAP, but the activity of methylated or ethylated TAP was almost the same as TAP.<BR>After pap a in digestion for 1 hour, the activity of acetylated TAP and TAP coupled with bis-diazotized benzidine did not reduce, but it reduced slightly in the case of TAP coupled with ο-aminophenol and markedly in the case of TAP and TAP coupled with sulfanylic acid.

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