トラネキサム酸およびグリチルリチン酸ジカリウム配合歯磨剤の歯周疾患予防効果に関する研究

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  • Clinical Evaluation of the Dentifrice Containing TranexamicAcid and Dipotassium Glycyrrhizinate for Periodontal Disease.

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The purpose of this study was to investigate the clinical effect of dentifrice R containing 0.05% tranexamic acid and 0.05% dipotassium glycyrrhizinate on the improvement of periodontal disease compared with dentifrice T containing 0.05% tranexamic acid.<BR>Subjects were 148 adults who had no serious oral or systemic diseases. They were divided into two groups equally and performed toothbrushing twice a day for four weeks with dentifrice R or T.<BR>The PMA index, redness, swelling, and plaque score were selected as indices for clinical evaluation of periodontal condition.<BR>The results obtained were as follows.<BR>1) Dentifrice R was significantly superior to dentifrice T in the improvement of PMA index (p<0.01), redness (p<0.01) and swelling (p<0.05). There was no significant difference in the improvement of plaque score between dentifrices R and T.<BR>2) The mean improvement rates of dentifrice R and dentifrice T were 37.0% and 26.3% in PMA index, 40.7% and 25.2% in redness, and 36.7% and 29.9% in swelling, respectively.<BR>3) No particular side effects were observed during this clinical study.

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