THE EFFECTS OF ANTITUBERCULOSIS CHEMOTHERAPY <I>IN VITRO</I> UNDER VARIOUS CONDITIONS INADEQUATE FOR THE GROWTH OF TUBERCLE BACILLI

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  • MAEKAWA Nobuo
    First Department of Medicine, Chest Disease Research Institute, Kyoto University
  • NAKANISHI Michiyasu
    First Department of Medicine, Chest Disease Research Institute, Kyoto University
  • KAWAI Mitsuru
    First Department of Medicine, Chest Disease Research Institute, Kyoto University
  • IKEDA Nobuaki
    First Department of Medicine, Chest Disease Research Institute, Kyoto University
  • NAKAI Hitoshi
    First Department of Medicine, Chest Disease Research Institute, Kyoto University

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Other Title
  • 結核菌の発育に不適当な条件と化学療法
  • ケッカクキン ノ ハツイク ニ フテキトウ ナ ジョウケン ト カガク リョウホウ 1 バイヨウ オンド ト カガク リョウホウザイ ノ コウカ
  • I. Incubating Temperature and Chemotherapeutic Effect
  • I.培養温度と化学療法剤の効果

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Description

Chemotherapeutic effects of INH alone and four-drug regimen of SM⋅INH⋅PAS⋅EB to Mycobacterium tuberculosis H37Rv were evaluated in vitro by changing the incubating temperature at 37°C, 25°C and 4°C.<BR>Comparing the results obtain e d at 25°C and 4°C with those at 37°C, the chemotherapeutic effects were remarkably lowered in the latter even in the four-drug regimen and the development of drug-resistance to INH was not observed in such an inadequate condition for the growth of tubercle bacilli.<BR>According to these results, it is almost impossible to intensify the antituberculosis chemotherapeutic effect under the condition inadequate for the growth of tubercle bacilli in vitro.

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