THE EFFECT OF CHEMOTHERAPY FOR ORIGINALLY TREATED CAVITARY TUBERCULOSIS PATIENTS WITH POSITIVE SPUTUM OBSERVED FOR TWO YEARS

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  • 初回有空洞排菌例に対する2年間の化療成績
  • ショカイユウクウドウハイキンレイ ニ タイスル 2ネンカン ノ カリョウセイセキ

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The effect of chemotherapy for originally treated cavitary tuberculosis patients was observed for two years.<BR>Two hundred and ninety two cases of previously untreated tuberculosis patients were adopted to this study. All these patients had cavity and positive sputum for tubercle bacilli at the beginning of chemotherapy, and were hospitalised and treated at least for the first six months with streptomycin, PAS and isoniazid.<BR>Tubercle bacilli in sputum conver ted to negative in 97.8% of the cases with nonsclerotic walled cavity after one year chemotherapy and in 99.1% after two years. In the cases with sclerotic walled cavity, negative conversion of bacilli was observed in 79.0% after one year chemotherapy, and 81.8% after two years.<BR>Improvement of cavity including c avity closure and cyst-like change of cavity wall less than 2 mm throughout entire circumference was observed in 78.7% of the cases with nonsclerotic walled cavity after one year chemotherapy and 81.8% after two years. In the cases with sclerotic walled cavity, the improvement of cavity was observed in 22.4% after one year and in 22.4% after two years.<BR>After completing one year chemotherapy, new improvement of cavity during the next one year chemotherapy was observed in 4.1% of the cases with small or medium size nonsclerotic walled cavity, in 13.9% of the cases with large, multilocular or multiple nonsclerotic walled cavity, and none of the cases with sclerotic walled cavity.

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