Streptomycin依存性結核菌を用いた増殖休止菌に対する抗結核剤の効果に関する研究

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書誌事項

タイトル別名
  • STUDIES ON THE EFFECTS OF ANTITUBERCULOSIS AGENTS AGAINST TUBERCLE BACILLI IN THE RESTING ST ATE, USING STREPTOMYCIN-DEPENDENT STRAIN (18-b)
  • Streptomycin イゾンセイ ケッカクキン オ モチイタ ゾウショク キュウシキン ニ タイスル コウケッカクザイ ノ コウカ ニ カンスル ケンキュウ 2 ドウブツ ジッケン
  • II. Studies <I>in vivo</I>
  • 第2編動物実験

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説明

To evaluate the chemotherapeutic effects of antituberculosis agents against tubercle bacilli in the resting state, the author made in vivo experiment by using streptomycin (SM)-dependent strain of tubercle bacilli (18-b), cultivated under SM-starving condition.<BR>Mice of dd-strain, infected intravenously by 18-b, are treate d with isoniazid (INH) alone or in combination with kanamycin (KM) and ethambutol EB for eight weeks. After treatment, colonies of tubercle bacilli recovered from lung and spleen of treated mice are recorded and compared with those of untreated mice and with mice infected with tubercle bacilli in normally growing state.<BR>According to the results of this experiment, chemotherapeutic effects of antituberculosis agents such as INH, KM and EB were hardly observed against SM-dependent strain of tubercle bacilli (18-b) in the resting state under SM-starving condition of mice.

収録刊行物

  • 結核

    結核 46 (12), 493-500, 1971

    一般社団法人 日本結核病学会

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