RIFAMPICIN IN THE RETREATMENT OF SEVERE CAVITARY PULMONARY TUBERCULOSIS

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  • Rifampicinによる肺結核の再治療
  • Rifampicin ニ ヨル ハイケッカク ノ サイチリョウ アト タイセイ , ケッチュウ ノウド , フクサヨウ

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Resistant test was carried out by proportion method using 1% Ogawa medium and cork stop. The results were read usually 4 weeks after incubation, but when the colonies on the control are too small, reading was done after 6 weeks. Preservation for 4 weeks at 20-22°C brought the slight reduction of activity in the media containing 2 mcg or 5 mcg of RFP but no change was seen in the media of 10 mcg or more.<BR>Sensitivity to 2 mcg, 5 mcg, 10 mcg, 20 m cg, 50 mcg, of RFP was studies in 112 human strains isolated from new cases, cases resistant to primary and or secondary drugs, 4 strains of M. kansasii and 5 non photochromogens isolated from the patients. All 5 strains of non photochromogens were completely resistant to 50 mcg. All the human strains and M. kansasii showed nearly the same sensitivity to RFP, and there were no strains which grow more than 20% of the control on 5 mcg and 1% on 10 mcg or more. However, measuring on 2 mcg level. the more the number of resistants drugs, the higher the sensitivity to RFP.

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