<I>Streptococcus mutans</I>の菌体外グルコシルトランスフェラーゼ投与による実験齲蝕の誘発の試み

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  • An Attempt at Plaque Formation and Caries Induction in Rodents by Oral Administration of Extracellular Glucosyltransferase from <I>Streptococcus mutans</I>
  • Streptococcus mutans ノ キンタイガイ グルコシル トラン

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In a previous study we demonstrated that the cells of nonadhering Streptococcus mutans AHT mutants and Escherichia coliand the inert resin particles adhere to glass when incubated with extracellular glucosyltransferase (GTF) from S. mutans AHT and sucrose. The results prompted us to examine whether oral inhabitants other than S. mutans can induce plaque formation and subsequent development of dental caries in rodents by providing them with sucrose-containing diet and cellfree GTF soultion.<BR>The cells of Lactobacillus casei PSR 3002 and indigenous flora in the plaque collected from the molars of golden hamsters adhered to glass when incubated with sucrose and cell-free GTF from S. mutans AHT-SMRI. However, L. casei did not establish itself in the mouth of penicillin-pretreated SD rats reared on cariogenic diet # 2000 and cell-free GTF solution. Consequently, no carious lesions developed on the molars of the rodents. The oral administration of GTF as a drinking fluid neither significantly induced microbial plaque formation nor caries development in the sucrose-fed golden hamsters harbouring indigenous lactobacilli. In this case, however, the extent of plaque formation and caries development of the GTFadministered animals was higher than those of the control animals provided with distilled water.<BR>No decisive conclusion can be drawn from these results. There still remains a possibility that tenacious glucans produced by extracellular GTF of S. mutans could induce non-specific adherence of oral bacteria and thus that they are involved in the formation of microbial deposits and subsequent development of carious lesions on teeth. A decisive conclusion must await further study.

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