Clinical Study of Early Laryngeal Cancer

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  • Nagatani Gunji
    Department Otorhinolaryngology, School of Medicine, University of Occupational and Environmental Health
  • Mori Takanori
    Department Otorhinolaryngology, School of Medicine, University of Occupational and Environmental Health
  • Udaka Tsuyoshi
    Department Otorhinolaryngology, School of Medicine, University of Occupational and Environmental Health
  • Shiomori Teruo
    Department Otorhinolaryngology, School of Medicine, University of Occupational and Environmental Health
  • Ohbuchi Toyoaki
    Department Otorhinolaryngology, School of Medicine, University of Occupational and Environmental Health
  • Suzuki Hideaki
    Department Otorhinolaryngology, School of Medicine, University of Occupational and Environmental Health

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Other Title
  • 早期喉頭癌に対する臨床的検討
  • ソウキ コウトウ ガン ニ タイスル リンショウテキ ケントウ

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We retrospectively analyzed 71 consecutive cases of early laryngeal cancer (stage I or II) that had undergone primary treatment in our department between 1999 and 2004. There were 68 males and 3 females, and their ages ranged from 40 to 85 years of age (average ; 67.7 years). Eight patients had the supraglottic type, 61 had the glottic type, and 2 had the subglottic type. Chemoradiotherapy was performed as the primary treatment except in the patients with glottic T1a cancer, who received radiotherapy alone.<br>The 5-year survival rates was 91.1% for glottic cancer (T1a : 100%, T1b : 92.3%, T2 : 85.8%) and 75.0% for supraglottic cancer. The local control rate of glottic cancer was 79.6% (T1a : 80.0%, T1b : 74.0%, T2 : 85.2%), and significantly higher than that of supraglottic cancer (56.2%, p<0.05). The laryngeal preservation rate was 84.4% in glottic cancer (T1a : 100%, T1b : 76.9%, T2 : 77.5%) and 58.3% in supraglottic cancer, and the difference between T1a and T2 glottic cancer was significant (p<0.05). Local recurrence and cervical lymph node metastasis were seen in 9 patients and 6 patients, respectively. Distant metastasis occurred in 4 patients, all of whom had the glottic type. Four patients died of their disease, and distant metastasis was the major cause of death in 3 of them.<br>These results indicate that additional treatment should be performed in cases in which radiotherapy/chemoradiotherapy is ineffective and that both in the early stages glottic and supraglottic cancers can be successfully treated by radiotherapy/chemoradiotherapy.<br>The results also suggested that the survival of patients with early laryngeal cancer depends on whether they develop distant metastasis. Introduction of adjuvant chemotherapy to improve their prognosis remains to be assessed.

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