A Study of Serum Protein Fractions of Normal Population

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  • UEDA Yuko
    Department of Epidemiology and Environmental Medicine, Medical Reserch Institute, Tokyo Medical and Dental University
  • OHBA Hiroshi
    Department of Epidemiology and Environmental Medicine, Medical Reserch Institute, Tokyo Medical and Dental University
  • YANAGISAWA Fumiyoshi
    Department of Epidemiology and Environmental Medicine, Medical Reserch Institute, Tokyo Medical and Dental University

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Other Title
  • 健常者の血清蛋白分画に関する研究
  • ケンジョウシャ ノ ケッセイ タンパク ブンカク ニカンスルケンキュウ トクニ
  • -With Special Reference to Analysis of Their Normal Ranges-
  • ―とくに正常値の範囲についての解析―

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Abstract

The authors assased the serum samples from 536 men and 617 women selected out of the examinees in the mass surveys made in four rural districts for serum protein fractions by electrophoresis using the cellulose acetate membrane (Separax) as a supporting medium. With the subjects with the total serum protein (T. P.) in the range of 6.5≤T. P.≤8.0 g/dl by refraction analysis as normal group (consisting of 488 men and 557 women), the determined values of the serum protein fractions of this group were analyzed by the two sexes, age groups and districts ; and the following were found; Out of the serum protein fractions, there was a difference in the concentration of albumin fraction and also in that of γ-globulin fraction between the two sexes. The concentration of each fraction altered in various ways with ageing and also altered differently with each sex ; generally speaking, however, the albumin fraction tended to decrease, and the γ-globulin fraction tended to increase with ageing. There was no apparent difference in the concentration of any fractions between the districts. When M±2SD was calculated in terms of the concentration ratios (%) of serum protein fractions from the mean and standard deviation of the normal group, the albumin fraction was rated 57.35 -70.87, the α1-globulin, 2.27 - 4.91, the α2-globulin, 6.42 - 11.78, the β-globulin, 5.78 - 10. 18, the γ-globulin, 9.54 - 20.85, and the A/G ratio, 1.29 - 2.33 in the men, and the albumin fraction was rated 55.41 - 69.29, the αl-globulin, 2.32 - 4.92, the α2-globulin, 6.26 -11.38, the β-globulin, 5.69 - 10.61, the γ-globulin, 11.53 - 22.49, and the A/G ratio, 1.18 - 2.18 in the women ; therefore, we propose these ranges of fraction concentrations as their normal ranges.

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