血中ラミニンγ２鎖濃度測定による頭頸部癌診断に関する検討

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タイトル別名
  • Blood Concentration of Laminin .GAMMA.2 Chain in Patients with Head and Neck Cancer
  • ケッチュウ ラミニン ガンマ 2 サ ノウド ソクテイ ニ ヨル トウケイブガン シンダン ニ カンスル ケントウ

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Laminin γ2 chain (LN γ2), expressed in human cancer cells and correlated with cancer malignancy, is cleaved by proteases and secreted into circulation. We measured the blood concentration of LN γ2 in patients with head and neck cancer by an immuno-fluorescence assay using monoclonal antibodies against human LN γ2. The normal blood concentration of LN γ2 was estimated to be less than 50ng/ml. Among 60 patients with head and neck cancer, 40 (67%) showed normal LN γ2 concentration less than 50ng/ml and 20 (33%) increased concentration exceeding 50ng/ml. The relative ratio of the number of patients who showed increased LN γ2 concentration correlated with the clinical stages of cancer. The blood concentration of LN γ2 in 24 who initially showed normal concentrations did not change after radical treatments. Five who initially showed increased LN γ2 concentration showed decreased concentration of less than 50ng/ml after radical treatment. Four showed increased LN γ2 concentration after treatment, and presented residual cancer, which killed them. Three of the 4 patients showed marked increase in LN γ2 concentration exceeding 100ng/ml and developed multiple distant metastases to the lung, liver, bone, and skin. The blood concentration of LN γ2 in patients with head and neck cancer may thus indicate the amount of highly malignant cancer cells expressing LN γ2. The blood concentration of LN γ2 could therefore serve as a new tumor marker that might indicate the malignancy of and efficacy of treatments for head and neck cancer.

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