IN VITRO ANTI-TUMOR ACTIVITY OF HUMAN BLOOD MONOCYTES AGAINST CULTURED HUMAN CANCER CELLS

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  • KONISHI KAZURO
    Department of Otolaryngology, Niigata University School of Medicine

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  • ヒト培養がん細胞に対する単球の抗しゅよう性
  • ヒト バイヨウ ガン サイボウ ニ タイスル タンキュウ ノ コウ シュヨウセ

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Abstract

Anti-tumor activity of the human blood monocytes against cultured human cancer cells was examined in vitro. The cell lines used in this study were Okajima (a stomach cancer), KatoIII (a stomach cancer) and Hattori (a breast cancer).<br>The anti-tumor activity of the monocytes from healty volunteers was not detected by 51Crrelease assay of the target tumor cells, but was demonstrated by 3H-thymidine incorporation test. This suggested that the anti-tumor activity was attributed to the cytostatic action. The inhibition of the growth of the tumor cells was observed irrespective of their origin. The growth of human normal fibroblasts was not inhibited by the activity of the monocytes.<br>The anti-tumor activity was enhanced by in vitro treatment of monocytes with immunopotentiaters, such as Propionibacterium acnes (P. acnes), P. acnes-cell wall skeleton (CWS), a streptococcal preparation (OK-432) and Nocardia-rubra-CWS. The activity was not enhanced by protein bound polysaccharide Kureha (PSK).<br>The activity of the monocytes from human umbilical cord blood was almost same to that of peripheral blood monocytes from healthy volunteers. The antitumor activity of peripheral blood monocytes from patients with head and neck cancer was also almost same to that of monocytes from healthy volunteers and was enhanced by the treatment with those immunopotentiaters in vitro.

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