MALIGNANT TRANSFORMATION OF LARYNGEAL PAPILLOMAS

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  • ISHII HIDEO
    Department of Otorhinolaryngology, Gunma University, School of Medicine
  • KAWABATA ISUZU
    Department of Otorhinolaryngology, Tokyo University, School of Medicine

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  • 癌化したと思われる喉頭乳頭腫
  • ガンカシタ ト オモワレル コウトウ ニュウトウシュ

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Abstract

In the past 14 years, 32 patients (22 males and t0 females) of the laryngeal papilloma were treated at the Department of Otolaryngology, Gunma University Hospital. Most of them were in a range of 30-60 years of age. Ten out of 32 patients were in sixties. Only one patient was under 10 years of age. <br>On laryngoscopic examinations the lesions showed hyperkeratotic appearances. The child showed atypical findings from those of the so-called multiple juvenile papilloma. <br>Patients with the localized type papilloma were completely cured by surgery. However, the diffuse type papilloma was resistant to either radiotherapy or chemotherapy. <br>From long-term follow up studies, was observed in 5 patients (all males) malignant transformation. An interval between the onset of the symptom (hoarseness) and malignant transformation was from 4 to 9 years.<br>Laryngectomy was performed for all patients. Three cases out of then were examined by serial large sections and it was shown that the tumor extended to the underlying tissue and that in one case it invaded the laryngeal cartilage. <br>All of them servived without evidence of recurrence or metastasis.

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