口腔,咽頭の深在性Candida Mycosisの組織学的診断について

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タイトル別名
  • HISTOLOGICAL DIAGNOSIS OF SUBMUCOUS CANDIDA MYCOSIS OF THE MOUTH AND PHARYNX.
  • コウクウ , イントウ ノ シンザイセイ Candida Mycosis ノ ソシキガクテキ シンダン ニ ツイテ

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Candida albicans infection of the mouth and pharynx is divided into two types, namely superficial candidiasis and deep-seated submucous candidiasis. The former is well-known to public as thrush. Histologically it is a localized necrosis of the superficial layer of the mucosa.<br>The latter is rare and it is called sometimes chronic thrush, which shows strong resistance against any treatment and takes prolonged course.<br>It is not easy to diagnose this chronic candida ulcer, because the histological findings are not well known.<br>The author and his co-operators had studied clinically as well as experimentally on this problem.<br>The characteristic findings of oral and pharyngeal ulcer will be described briefly in this paper.<br>The fixed tissue of this granulation is consisted of fibroblasts and endothelial cells. Proliferation of the endothelial cells has close relationship to regeneration of the capillaries. Remarkabl regeneration of the capillaries is the most chareacteristics findings of the granulation in this disease. The histiocytes were found commonly among the infiltrating cells. The giant cells are usurely present, it is not easy to confirm it, unless one recognize carefully the none-typical or abortive, which must have emerged from the edndothelial cells of the capillaries.<br>For exact diagnosis of candidiasis it is required to confirm the presence of candida in the granulation tissue. It is, however, highly difficult to discover the myces in the granulation tissue. Therefore, the author feels at present that the diagnosis of candidiasis should be made if the specimen from the ulcer reveals the above mentiond findings, even without confirmation of typical myces in the granulation nissues.

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