扁桃組織中の遊離アミノ酸分画について

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タイトル別名
  • AN INVESTIGATION OF THE CONCENTRATION OF FREE AMINO ACIDS IN TONSILS
  • 扁桃組織中の遊離アミノ酸分画について--アミノ酸代謝経路よりみた扁桃の機能並びに病態の検討
  • ヘントウ ソシキチュウ ノ ユウリ アミノサン ブンカク ニ ツイテ アミノサ
  • AN EVALUATION OF THE TONSILLAR FUNCTION AND PATHOLOGY

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For the purpose of investigating the function of tonsils, seventeen kinds of free amino acids (Isoleucine, Leucine, Lysine, Methionine, Phenylalanine, Threonine, Valine, Alanine, Glycine, <br>Proline, Glutamic acid, Serine, Tyrosine, Aspartic acid, Cystine, Histidine, and Arginine) were analysed by an automatic amino acid analyser (JLC-6AH) for the tonsillar tissues taken from 70 cases.<br> The plasma specimens which were taken at the pre- and post-operative periods were also analysed in 50 of the above cases.<br>The free amino acids were divided into 3 groups as glucogenic, ketogenic and others according to their metabolic pathways. The results of the present study are summarized as follows:<br>1) The amount of free glucogenic amino acids is much larger than that of ketogenic amino acids in the tonsillar tissues.<br>2) It is found that the level of glucogenic amino acids fluctuates significantly in the tonsillar tissues. Namely, the level increases in hypertrophied tonsils, in the non-inflammatory stage, and also according to the degree of hypertrophy. The level decreases in acute tonsillitis and in the group having high serum ASO titers. There is no significant fluctuation in the level of ketogenic amino acids.<br>3) As for the amino acid level in the postoperative plasma, the level of glucogenic amino acids increases in aged subjects, in the first degree of hypertrophy and in the group showing high serum ASO titers, while it decreases in acute tonsillitis.<br>The level of ketogenic amino acids increases in accordance with aging and decreases in acute tonsillitis. The other amino acids increase with aging and also in the first degree hypertrophy, while decrease during the intermediate period of tonsillitis.<br>4) Here is -- tendency to decrease in the level of the plasma free amino acids during the period of 4 weeks after tonsillectomy. Particularly, the level of all types decreases with aging, in focal tonsillitis, in inflammatory stage, in the first degree hypertrophy and in the group showing high serum ASO titers. On the other hand, the tendency is found only for the levelsof glucogenic and ketogenic types in acute tonsillitis and for that of the other amino acids in hypertrophied tonsils. In the third degree hypertrophy, the levels of ketogenic and other amino acid types show decreasing tendency. No elevation is found for the level of the plasma amino acids during the post-operative period.

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