STUDIES ON DIAGNOSIS OF NASAL ALLERGY WITH SPECIAL

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  • 鼻アレルギーの診断に関する研究
  • 鼻アレルギーの診断に関する研究--特にIgEを中心にして
  • ビ アレルギー ノ シンダン ニカンスルケンキュウ トクニ IgE オ チュウ
  • REFERENCE TO IgE

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Abstract

IgE content and specific IgE antibodies to mites (dermatophagoides farinae) and alternaria were determined in sera and nasal secretions from 166 patients with nasal allergy, 40 patients with bronchial asthma and 50 control subjects, using radioimmunosorbents test (RIST) and radioallergosorbent test (RAST). Out of 166 patients with nasal allergy, 109 (66%) were allergic to house dust (HD) or mites, 29 (17%) to pollen of Japanese ceder and 9 (5%) to<br>Alternaria. Other causative allergens were pollen of ragweed and cock's foot and Candida.<br>Mean concentrations of IgE in both serum and nasal secretion were significantly greater in groups of nasal allergy and bronchial asthma than in the control group. However, in 24% of the patients with nasal allergy the IgE content was below the mean value of the control group.<br>The mean IgE concentration of serum and nasal secretion was significantly greater in patients with marked eosinophilia in nasal secretion and peripheral blood than those with no eosinophilia.<br>In HD allergy the RAST scores were significantly correlated with the reactivity to HD skin tests, the amount of eosinophiles in nasal secretion and peripheral blood and the IgE contents in serum and nasal secretion. The results of the present study showed the usefulness of the determination of IgE and specific IgE antibodies in the diagnosis of nasal allergy. RAST for estimation of specific reaginic antibodies was more clinically useful than the measurement of<br>IgE concentration. IgE in nasal secretion was much more closely related to pathogenesis of respiratory allergies than was IgE in serum.

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