Histological Study of Autologous Fascia Implantation with Basic Fibroblast Growth Factor in Rats Leg Muscle

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  • 塩基性線維芽細胞増殖因子（ｂ‐ＦＧＦ）を用いた自家筋膜移植の組織学的検討―ラットの下肢筋を用いて―
  • 塩基性線維芽細胞増殖因子(b-FGF)を用いた自家筋膜移植の組織学的検討--ラットの下肢筋を用いて
  • エンキセイ センイ ガサイボウ ゾウショク インシ b FGF オ モチイタ ジカ キンマク イショク ノ ソシキガクテキ ケントウ ラット ノ カシキン オ モチイテ

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Abstract

Autologous transplantation of a fascia graft as a treatment for unilateral vocal fold paralysis does not prevent resorption of the implanted material after surgery. Therefore, we attempted implantation between the control-release of the basic fibroblast growth factor (b-FGF), which was impregnated into a gelatin hydro gel sheet, to assess whether or not the autologous fascia may increase the survival rate of the implanted fascia. We used SD rats and implanted these materials into the gastrocnemius muscle. The survival rate of the implanted fascia with b-FGF was significantly higher compared with the implanted fascia without b-FGF at 4 weeks after surgery (p=0.03). The volume of granulation tissue around the implanted fascia with b-FGF was significantly larger compared with the implanted fascia without b-FGF at 2 weeks after surgery (p=0.03). The implantation with b-FGF correlated significantly with the volume of the implanted fascia and the granulated tissue (p=0.019). These results suggest that the presented implantation, intended to interact with the control-release of b-FGF, may protect the implanted fascia in such way that it will be covered by severely granulated tissue and avoid resorption in the body. We believe that this type of implantation could be a beneficial treatment for unilateral vocal fold paralysis.

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