Clinicopathological Study of Salvage Surgery in Recurrent Hypopharyngeal Carcinoma after Chemoradiotherapy

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  • Maeda Akiteru
    Department of Otolaryngology-Head and Neck Surgery, Kurume University School of Medicine
  • Chitose Shunichi
    Department of Otolaryngology-Head and Neck Surgery, Kurume University School of Medicine
  • Umeno Hirohito
    Department of Otolaryngology-Head and Neck Surgery, Kurume University School of Medicine
  • Chijiwa Hideki
    Department of Otolaryngology-Head and Neck Surgery, Kurume University School of Medicine
  • Mihashi Hiroyuki
    Department of Otolaryngology-Head and Neck Surgery, Kurume University School of Medicine
  • Nakashima Tadashi
    Department of Otolaryngology-Head and Neck Surgery, Kurume University School of Medicine
  • Fujita Hiromasa
    Department of Surgery, Kurume University School of Medicine

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Other Title
  • 化学放射線治療後の再発下咽頭癌に対する救済手術とその臨床病理学的検討—原発巣の浸潤様式について—
  • 化学放射線治療後の再発下咽頭癌に対する救済手術とその臨床病理学的検討 : 原発巣の浸潤様式について
  • カガク ホウシャセン チリョウ ゴ ノ サイハツ カ イントウガン ニ タイスル キュウサイ シュジュツ ト ソノ リンショウ ビョウリガクテキ ケントウ : ゲンパツ ソウ ノ シンジュン ヨウシキ ニ ツイテ

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Abstract

We analyzed the surgically removed organs from 17 histopathologically recurrent hypopharyngeal carcinomas after chemoradiotherapy performed between 1989 and 2010. The overall survival rate was 37%,the cause-specific survival rate was 45% and the local control rate was 54%.Postoperative complications were found in 12 cases (71%). After salvage surgery 6 cases survived, 8 cases died from the primary lesion, 1 case died from lung metastasis and 1 case died from other causes. Invasion to the larynx was found in 11 cases (65%). The characteristic pattern of invasion from the primary lesion was found to be a submucosal extension of the cancer cells.

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