The Effect of Butropium Bromide as a Premedication for Depression of Salivation on Endoscopic Examination

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  • 内視鏡検査時における臭化ブトロピウムの分泌抑制効果について
  • ナイシキョウ ケンサジ ニ オケル シュウカ ブトロピウム ノ ブンピ ヨクセ
  • Using Double Blind Technique
  • 二重盲検法による検討

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Abstract

The effect of butropium bromide, which is a synthetic anti-cholinergic drug and used as premedication mainly for depression of salivation inhibiting the endoscopic examination, was researched by the double blind controlled method.<BR>Among 50 subjects, 25 cases were given butropium bromide (B.B. group) and the rest 25 were given a placebo.(placebo group).<BR>They were examined on 4 items, i. e., the reflexion depressing effect, the secretion depressing effect, the movement depressing effect, and the antalgic effect.<BR>On the test of the reflesion depressing effect, the effective ratio was 64% in both groups and no significant difference was obtained.<BR>The effective ratio of the secretion depressing effect was 80% in the B.B. group and 36% in the placebo group. A significant difference was observed with a level of P<0.005.<BR>The effective ratio of the movement depressing effect was 60% in the B.B. group and 36% in the placebo one: the difference was observed with a level of P<0.1.<BR>The effective ratio of the antalgic effect was 60% in the B.B. group and 32% in the placebo one; the significant difference was at a level of P<0.05.<BR>As side effects, 2 cases in the B.B. group showed nausea, etc., but they were slight.<BR>It was concluded that butropium bromide given as a premedicament for endoscopic examination was particularly effective on depression of secretion, and was very useful.

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