Prognostic Factors in Patients with Nasopharyngeal Carcinoma

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  • Obata Kazufumi
    Division of Head and Neck Surgery, Cancer Institute Hospitalof the Japanese Foundation For Cancer Research (JFCR) Department of Otolaryngology Sapporo Medical University
  • Yonekawa Hiroyuki
    Division of Head and Neck Surgery, Cancer Institute Hospitalof the Japanese Foundation For Cancer Research (JFCR)
  • Sato Yukiko
    Department of Pathology, Cancer Institute of the Japanese Foundation For Cancer Research (JFCR)
  • Kawabata Kazuyoshi
    Division of Head and Neck Surgery, Cancer Institute Hospitalof the Japanese Foundation For Cancer Research (JFCR)
  • Mitani Hiroki
    Division of Head and Neck Surgery, Cancer Institute Hospitalof the Japanese Foundation For Cancer Research (JFCR)
  • Fukushima Hirofumi
    Division of Head and Neck Surgery, Cancer Institute Hospitalof the Japanese Foundation For Cancer Research (JFCR)
  • Sasaki Tohru
    Division of Head and Neck Surgery, Cancer Institute Hospitalof the Japanese Foundation For Cancer Research (JFCR)
  • Shimbashi Wataru
    Division of Head and Neck Surgery, Cancer Institute Hospitalof the Japanese Foundation For Cancer Research (JFCR)
  • Seto Akira
    Division of Head and Neck Surgery, Cancer Institute Hospitalof the Japanese Foundation For Cancer Research (JFCR)
  • Ebina Aya
    Division of Head and Neck Surgery, Cancer Institute Hospitalof the Japanese Foundation For Cancer Research (JFCR)
  • Kamiyama Ryosuke
    Division of Head and Neck Surgery, Cancer Institute Hospitalof the Japanese Foundation For Cancer Research (JFCR)
  • Hidaka Ryuta
    Division of Head and Neck Surgery, Cancer Institute Hospitalof the Japanese Foundation For Cancer Research (JFCR)
  • Kondo Takahito
    Division of Head and Neck Surgery, Cancer Institute Hospitalof the Japanese Foundation For Cancer Research (JFCR)
  • Uezato Jin
    Division of Head and Neck Surgery, Cancer Institute Hospitalof the Japanese Foundation For Cancer Research (JFCR)
  • Hattori Masakatsu
    Division of Head and Neck Surgery, Cancer Institute Hospitalof the Japanese Foundation For Cancer Research (JFCR)
  • Himi Tetsuo
    Department of Otolaryngology Sapporo Medical University

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Other Title
  • 上咽頭癌における Epstein-Barr virus 関連の有無と予後因子
  • ジョウイントウ ガン ニ オケル Epstein-Barr virus カンレン ノ ウム ト ヨゴ インシ

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<p>　 Background: The prognosis of Epstein-Barr virus-encoded small RNA (EBER)-positive nasopharyngeal carcinoma (NPC) is reportedly good, however, how EBER affects the prognosis of NPC remains unclear.</p><p>　Methods: We retrospectively analyzed the clinical outcomes and prognostic factors in patients with NPC who received the initial treatment at the Cancer Institute Hospital between 2005 and 2012. We examined the overall survival, progression-free survival and independent prognostic factors such as the age, sex, TNM classification, stage, pathological findings, tumor site and presence/absence of EBER among 50 patients with NPC. We also evaluated the correlations between the presence/absence of EBER and the pathological findings of NPC/the disease-related mortality.</p><p>　 Results: The five-year overall and progression-free survival rates were 76.0% and 61.4%, respectively. Univariate analysis revealed significant differences in the overall survival, EBER, pathological findings, M classification and stage classification. Significant differences were also noted in the progression-free survival, prevalence of EBER, pathological findings, N and M classification and stage classification. Multivariate analysis identified pathological findings and stage classification as independent prognostic factors for the overall and progression-free survival. We also found a correlation between the presence/absence of EBER and the pathological findings.</p><p>　In the case of WHO type II and III NPC, the site of the tumor at the time of death was often distant metastasis. On the other hand, in the case of WHO type I, primary carcinoma and neck lymph node metastases were predominant.</p><p>　Conclusion: Pathological findings and stage classification were identified as independent prognostic factors for the overall survival and progression-free survival in patients with NPC. Presence/absence of EBER was not an independent prognostic factor for NPC, but could affect the prognosis after treatment is administered. These factors are important for planning the treatment and subsequent follow-up of NPC.</p>

Journal

  • Nippon Jibiinkoka Gakkai Kaiho

    Nippon Jibiinkoka Gakkai Kaiho 120 (11), 1318-1327, 2017

    Japanese Society of Otorhinolaryngology-Head and neck surgery

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