HLA Antigens in Sinobronchial Syndrome

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  • Suzaki Harumi
    Department of Otorhinolaryngology, Faculty of Medicine, University of Tokyo
  • Kudoh Shoji
    Department of Internal Medicine, Komagome Hospital
  • Sugiyama Yukihiko
    The Third Department of Internal Medicine, Faculty of Medicine University of Tokyo
  • Maeda Hiroo
    The Blood Transfusion Service, Faculty of Medicine, University of Tokyo

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  • 副鼻こう気管支症候群におけるＨＬＡ抗原の検討
  • フクビクウ キカンシ ショウコウグン ニ オケル HLA コウゲン ノ ケント

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Abstract

Sinobronchial syndrome is defined as a coexisting pathology of chronic sinusitis and nonspecificchronic inflammatory lesion of the lower airway (e. g. chronic bronchitis, bronchiectasis, and diffuse panbronchiolitis).<BR>Forty six patients with sinobronchial syndrome and 184 normal controls were typed for HLA-A, B, C antigens.<BR>Significant findings obtained after HLA data analysis in sinobronchial syndrome were asfollows; HLA-Bw54 was found in 50.0 percent as compared to 11.4 percent in the controls (X2=33.0, corrected P=8.31×10-3, relative risk 7.76). HLA-Bw54 in diffuse panbronchiolitiswas found more frequently in 68.4 percent (X2=36.2, corrected P=2.04×10-9, relative risk16.8).<BR>Sinobronchial syndrome, especially diffuse panbronchiolitis, was associated with HLA-Bw54, which was found specifically in Japanese and not in Caucasians. These facts may suggestthat there is a gene controlling the susceptibility to sinobronchial syndrome, especially diffusepanbronchiolitis, and linked with a Japanese-specific HLA antigen.

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