書誌事項
- タイトル別名
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- Plasma Cell Interstitial Pneumonia as a Manifestation of Multicentric Castleman's Disease.
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説明
A 12-year-old boy was admitted to our hospital because of abnormal shadows on a chest radiograph, slight fever, and superficial lymphadenopathy. Laboratory examination showed anemia (Hb 9.9g/dl) and hyperimmunoglobulinemia (IgG 5469mg/dl) without M protein. A chest CT scan showed bilateral diffuse shadows and bilateral hilar lymphadenopathy. Biopsy specimens of an inguinal lymph node and a lung showed many lymphoid follicles with germinal centers, and marked infiltration of mature plasma cells in the interfollicular area without destruction of follicular structures. The polyclonality of the plasma cells was confirmed by immunohistochemistry. The patient was not treated because these results excluded malignant disease and he was asymptomatic. At the age of 17 years, he was admitted to our hospital again because of dyspnea and a tendency to bleed. Interstitial pneumonia, hyperimmunoglobulinemia (IgG 13900mg/dl), and anemia (Hb 6.6g/dl) were found, along with thrombocytopenia (2.5×104/mm3) and proteinuria. The serum interleukin-6 level was high: 177pg/ml. Bronchoalveolar lavage fluid contained many plasma cells. Therapy with corticosteroids and immunosuppressant medication was effective. Our diagnosis was plasma cell interstitial pneumonia as a manifestation of multicentric Castleman's disease.
収録刊行物
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- 日本胸部疾患学会雑誌
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日本胸部疾患学会雑誌 35 (7), 776-783, 1997
社団法人 日本呼吸器学会
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詳細情報 詳細情報について
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- CRID
- 1390282679993145984
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- NII論文ID
- 130003679801
- 10006602640
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- NII書誌ID
- AN00187758
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- COI
- 1:STN:280:DyaK1c%2FgtVCjsg%3D%3D
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- ISSN
- 1883471X
- 03011542
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- PubMed
- 9341283
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- 本文言語コード
- ja
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- 資料種別
- journal article
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- データソース種別
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- JaLC
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可