-
- 岡村 明治
- 新潟大学医学部病理学教室
書誌事項
- タイトル別名
-
- Therapeutic and Side Effects of Bleomycin with Special Reference to Bleomycin Pneumonitis
- Part 1: Therapeutic Effects
- 第1編 腫瘍に対するブレオマィシンの治療効果
この論文をさがす
説明
Fourty autopsy cases of malignant tumors treated with Bleomycin were studied histopathologically on therapeutic effects.<br>1) Bl vomycin was remarkably effective on some squamous cell carcinomas, especially carcinoma of the vulva. Similar effects were proved on carcinoma of the tongue and the upper jaw. But on squamous cell carcinoma of the esophagus and the lung the drug was less effective than those above mentioned, and was almost ineffective on adenocarcinoma of the lung, malignant mixed tumor of the parotis and reticulum cell sarcoma, and it showed no effect on scirrhous carcinoma of the stomach and small cell carcinoma of the lung.<br>2) Histological manifestation of curative effect on squamous cell carcinoma was observed as follows: degeneration and coagulation necrosis of tumor cells with abnormally increased keratinization of central parts of tumor nests for the first step, and the necrosis of greater part of tumor nests with the development of surrounding granulation tissue, which formed foreign body granuloma, for the second, and complete disappearance of the tumor tissue with replacement by scar tissue for the final.<br>3) Histological difference between the spontaneous local healing of squamous cell carcinoma and effects of Bleomycin were described.
収録刊行物
-
- 日本胸部疾患学会雑誌
-
日本胸部疾患学会雑誌 11 (5), 270-277, 1973
社団法人 日本呼吸器学会