An Autopsy Case of Dermatomyositis Associated with Interstitial Pneumonia Probably due to Cytomegalovirus Infection.
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- Nishi Kouichi
- Division of Pulmonary Medicine, Ishikawa Prefectural Central Hospital
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- Myoh Shigeharu
- Division of Pulmonary Medicine, Ishikawa Prefectural Central Hospital
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- Bandoh Takuma
- Division of Pulmonary Medicine, Ishikawa Prefectural Central Hospital
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- Ohka Takio
- Division of Pulmonary Medicine, Ishikawa Prefectural Central Hospital
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- Kurumaya Hiroshi
- Division of Pathology, Ishikawa Prefectural Central Hospital
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- Yasui Masahide
- The Third Department of Internal Medicine, School of Medicine, Kanazawa University
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- Fujimura Masaki
- The Third Department of Internal Medicine, School of Medicine, Kanazawa University
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- Matsuda Tamotsu
- The Third Department of Internal Medicine, School of Medicine, Kanazawa University
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- Shiobara Shintaroh
- Division of Blood Transfusion, School of Medicine, Kanazawa University
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- Minato Hiroshi
- The Second Department of Pathology, School of Medicine, Kanazawa University
Bibliographic Information
- Other Title
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- サイトメガロウイルスによると考えられる間質性肺炎を合併した皮膚筋炎の１剖検例
Abstract
An autopsy case of dermatomyositis (DM) associated with interstitial pneumonia probably due to cytomegalovirus infection is reported. After corticosteroid therapy for 1 month, a 79-year-old man with DM developed acute respiratory failure due to interstitial pneumonia and died in spite of intensive respiratory care. By polymerase chain reaction method (PCR), DNA of cytomegalovirus (CMV) was detected in the bronchoalveolar lavage fluid (BALF). CMV was also detected by the method of conventional virus culture from BALF. These findings suggested that initial infection or reactivation of CMV had occurred in the lungs. The autopsy specimen revealed the findings of interstitial pneumonia compatible with CMV pneumonitis, but without the presence of intranuclear inclusion bodies. Although the present case of interstitial pneumonia should not strictly be diagnosed as definite CMV pneumonitis without the presence of intranuclear inclusion bodies in the lung tissue, initial infection or reactivation of CMV in the lungs may have contributed to the pathogenesis of interstitial pneummonia. In other cases of collagen vascular disease associated with interstitial pneumonia, CMV or other viruses may contribute to the pathogenesis of interstitial pneumonia.
Journal
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- The Japanese journal of thoracic diseases
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The Japanese journal of thoracic diseases 30 (11), 1975-1980, 1992
The Japanese Respiratory Society