書誌事項
- タイトル別名
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- Five Cases of Drug-induced Pneumonitis Due to Sho-saiko-to or Interferon-.ALPHA. or Both.
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説明
We encountered five cases of drug-induced pneumonitis due to Sho-saiko-to or interferon-α or both. In all 5 cases the underlying disease was chronic hepatitis or liver cirrhosis caused by hepatitis C virus.<br>Interferon-α alone was administered in one case, Sho-saiko-to alone was administered in two cases, and both were administered in two cases. Bronchoalveolar lavage was done in 4 cases. In three cases, lymphocytosis and abnormally low CD4/8 ratios were found on examination of bronchoalveolar lavage fluid. In the only case in which interferon-α alone was given the percentage of neutrophils in bronchoalveolar lavage fluid was abnormally high, and the adult respiratory distress syndrome developed. Lymphocyte stimulation tests were done in four cases, and in all four cases the only positive results were against Sho-saiko-to or against interferon-α. The frequency of drug-induced pneumonitis among patients with chronic hepatitis or liver cirrhosis was 0.7% in those given only Sho-saiko-to, 0.5% in those given only interferon-α, and 4.0% in those given both interferon-α and Sho-saiko-to. Therefore, pneumonitis due to Sho-saiko-to and to interferon-α is more likely to occur if these two drugs are given simultaneously.
収録刊行物
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- 日本胸部疾患学会雑誌
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日本胸部疾患学会雑誌 33 (12), 1361-1366, 1995
社団法人 日本呼吸器学会
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キーワード
詳細情報 詳細情報について
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- CRID
- 1390282679994376192
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- NII論文ID
- 130003450367
- 10006189629
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- NII書誌ID
- AN00187758
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- ISSN
- 1883471X
- 03011542
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- PubMed
- 8821988
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- 本文言語コード
- ja
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- 資料種別
- journal article
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- データソース種別
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- JaLC
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可
