Effects of Theophylline on Ventilatory Regulation in Patients with Chronic Obstructive Pulmonary Disease.
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- Ikeda Akihito
- Pulmonary Division, The Second Department of Internal Medicine, School of Medicine, Fukuoka University
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- Senju Shoji
- Pulmonary Division, The Second Department of Internal Medicine, School of Medicine, Fukuoka University
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- Toyoshima Hideo
- Pulmonary Division, The Second Department of Internal Medicine, School of Medicine, Fukuoka University
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- Miyahara Satoko
- Pulmonary Division, The Second Department of Internal Medicine, School of Medicine, Fukuoka University
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- Aritomi Takamichi
- Pulmonary Division, The Second Department of Internal Medicine, School of Medicine, Fukuoka University
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- Watanabe Kentaro
- Pulmonary Division, The Second Department of Internal Medicine, School of Medicine, Fukuoka University
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- Ishibashi Masayoshi
- Pulmonary Division, The Second Department of Internal Medicine, School of Medicine, Fukuoka University
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- Yoshida Minoru
- Pulmonary Division, The Second Department of Internal Medicine, School of Medicine, Fukuoka University
Bibliographic Information
- Other Title
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- 慢性閉塞性肺疾患のCO2換気調節に及ぼすテオフィリンの影響
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Abstract
The effects and the mechanism of single and long-term administration of theophylline on ventilatory regulation were investigated in patients with chronic obstructive pulmonary disease (COPD).<br>The ventilatory and mouth occlusion pressure (P0.1) responses during CO2 rebreathing were measured before and 4 hours after oral, single administration of theophylline in 15 patients with pulmonary emphysema, 15 patients with asthma and 10 healthy subjects. Ventilatory response to CO2 (VE/PACO<sub>2</sub>) was increased in patients with asthma and P0.1 response to CO2 (P0.1/PACO<sub>2</sub>) was increased in patients with pulmonary emphysema after single theophylline administration. In patients with pulmonary emphysema, the increase in P0.1 was more marked than that in maximum inspiratory pressure static (MIPS).<br>The effect of long-term administration of theophylline was studied in 8 patients with COPD and 8 patients with restrictive lung disease. In patients with COPD, P0.1/PACO<sub>2</sub> was significantly increased and the increase was maintained until three months later.<br>These findings suggest that theophylline is effective in improving ventilatory and occlusion pressure responses to CO2 in patients with asthma probably by its bronchodilating effect, and in patients with pulmonary emphysema by its direct effect on the ventilatory control system.
Journal
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- The Japanese journal of thoracic diseases
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The Japanese journal of thoracic diseases 31 (11), 1441-1448, 1993
The Japanese Respiratory Society