Genetical analysis of skin tests, RASTs and serum IgE level in families with bronchial asthma in relation to age.

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  • ぜん息家系における皮内反応，ＲＡＳＴ，および血清総ＩｇＥに関する遺伝学的検討　　特に年齢的要素を加味した検討

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Nineteen families (108 family members) including patients with bronchial asthma were studied in terms of HLA genotype, serum IgE level, skin tests and RASTs. The results of skin test and RASTs were varied in decades of age, and the highest percent positive of the tests as well as serum IgE level were observed in the 20's. From these results, we considered that the analysis of the results of skin test, RAST and serum IgE level should be performed in HLA identical siblings close in age. The following results were obtained:<br>1) Significant correlation of serum IgE level between younger and older HLA identical siblings was not obtained.<br>2) Significant correlations between HLA genotype and skin reactivities to house dust, mite, Candida, as well as between HLA genotypes and RAST were not observed.<br>3) The skin test results of house dust and mite were markedly correlated to the serum IgE level (P<<0.001 in both) except Candida, however they did not correlate to HLA genotype.<br>4) In the case of genetical analysis of skin test and RAST results in patients with allergies, the age of subjects should be considered.

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