Pleural-origin Malignant Lymphoma in an Elderly Patient with Chronic Empyema and Infection with the Epstein-Barr Virus.

DOI PubMed 1 Citations 12 References
  • Mitsugi Yasushi
    Department of Internal Medicine, Tachikawa Medical Center Omotemachi Hospital Department of Geriatric Medicine, Tokyo Medical College
  • Katsunuma Hideyo
    Department of Internal Medicine, Tachikawa Medical Center Omotemachi Hospital
  • Asano Tetsuichi
    Department of Internal Medicine, Tachikawa Medical Center Omotemachi Hospital Department of Geriatric Medicine, Tokyo Medical College
  • Ogawa Kimikazu
    Department of Internal Medicine, Tachikawa Medical Center Omotemachi Hospital Department of Geriatric Medicine, Tokyo Medical College
  • Sakurai Hirofumi
    Department of Internal Medicine, Tachikawa Medical Center Omotemachi Hospital Department of Geriatric Medicine, Tokyo Medical College
  • Nishimura Yoshitaka
    Department of Radiology, Tachikawa Medical Center
  • Satoh Keiichi
    Department of Pathology, Tachikawa Medical Center
  • Shin Kohichi
    Department of Geriatric Medicine, Tokyo Medical College
  • Takasaki Masaru
    Department of Geriatric Medicine, Tokyo Medical College

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Other Title
  • 慢性膿胸後発症した高齢者胸壁原発悪性リンパ腫の１例　　Ｅｐｓｔｅｉｎ　Ｂａｒｒ（ＥＢ）ウイルスとの関連性
  • Epstein Barr (EB) ウイルスとの関連性

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Description

A 73-year-old woman with a long-standing history of right-sided chronic empyema complained of lumbago. An artificial pneumothorax had been induced to treat pulmonary tuberculosis about 40 years previously. The year after she began to complain of lunbago, a tumor mass over the right anterior chest wall had grown rapidly. Pathologic examination revealed that it was a malignant lymphoma (Non-Hodgkin's lymphoma, diffuse large cell, B cell type). Chemotherapy with cyclophosphamide, adriamycin, vincristine, and prednisolone, and then radiation therapy were given. The patient responded very well. The tumor mass on the surface of the chest wall disappeared completely. She was alive and well and there was no evidence of recurrence at the seven-month follow-up examination. Analysis with the polymerase chain reaction showed that the tumor contained DNA of the Epstein-Barr virus. The chronic empyema and local infection with the Epstein-Barr virus might have been a factor in the development of the malignant lymphoma.

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