Effect of aging and physical inactivity on glucose tolerance and insulin sensitivity.

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  • Sato Yuzo
    Research Center of Health, Physical Fitness and Sports, Nagoya University
  • Yamanouchi Kunio
    The First Department of Internal Medicine, Aichi Medical University
  • Nakajima Hirohisa
    The First Department of Internal Medicine, Aichi Medical University
  • Shinozaki Takashi
    The First Department of Internal Medicine, Aichi Medical University
  • Fujii Satoru
    The First Department of Internal Medicine, Aichi Medical University
  • Chikada Naoto
    The First Department of Internal Medicine, Aichi Medical University
  • Suzuki Yoichiro
    The First Department of Internal Medicine, Aichi Medical University
  • Chikada Kiwami
    The First Department of Internal Medicine, Aichi Medical University
  • Kato Katsumi
    The First Department of Internal Medicine, Aichi Medical University
  • Oshida Yoshiharu
    Research Center of Health, Physical Fitness and Sports, Nagoya University
  • Ohsawa Isao
    The Third Department of Internal Medicine, Nagoya University School of Medicine

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Other Title
  • 加齢に伴う身体的非活動性の耐糖能及びインスリン感受性に及ぼす影響
  • カレイ ニ トモナウ シンタイテキ ヒ カツドウセイ ノ タイトウノウ オヨビ

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It has been well documented that glucose intolerance is associated with aging, but it is not yet clear whether this phenomenon is due to the aging process itself or is secondary to the appearance of other age-related conditions among which physical inactivity is one of most important variables. To evaluate the effect of aging process and/or physical inactivity on insulin action, this study was undertaken using the euglycemic insulin clamp technique and the oral glucose tolerance test (OGTT). Subjects without diabetes mellitus and other serious diseases consisted of 14 non-obese aged individuals and 10 young controls (YC group), ranging in age from 63 to 85yrs, and from 19 to 21yrs, respectively. The aged individuals were further divided into two groups (one was termed as the AS group, in which 7 aged subjects had been confined to bed for at least 3 months and the other was termed as the AC group in which 7 aged controls kept their daily physical activity such as walking). The results of OGTT did not show any remarkable differences between AC and YC groups. In the AS group, however, glucose intolerance and low insulin response during OGTT were observed. In view of the tissue insulin action, MCR, which is thought as a reliable marker for tissue insulin action, evaluated by euglycemic insulin clamp was 5.31±0.68, 8.57±1.20, 9.60±0.35ml/kg/min in the AS, AC and YC groups, respectively (AS<AC, p<0.05, AS<YC, p<0.01, AC<YCM, N.S.). These data are consistent with the view that the aging process itself might slightly decrease tissue insulin action without any remarkable changes in OGTT. However physical inactivity added to age could be a more prominant factor which causes both glucose intolerance and peripheral tissue insulin resistance.

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