Effects of Administration of Clostridium butyricum to Patients Receiving Long-Term Tube Feeding.

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  • Ito Izumi
    Department of Internal Medicine, Chubu National Hospital Department of Geriatrics, Nagoya University School of Medicine
  • Hayashi Toshio
    Department of Geriatrics, Nagoya University School of Medicine
  • Iguchi Akihisa
    Department of Geriatrics, Nagoya University School of Medicine
  • Endo Hidetoshi
    Department of Internal Medicine, Chubu National Hospital
  • Nakao Makoto
    Department of Hospital Pharmacy, Nagoya University School of Medicine
  • Kato Saori
    Department of Hospital Pharmacy, Nagoya University School of Medicine
  • Nabeshima Toshitaka
    Department of Hospital Pharmacy, Nagoya University School of Medicine
  • Ogura Yozo
    Department of Hospital Pharmacy, Nagoya University School of Medicine

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Other Title
  • 経管栄養施行中の高齢患者腸粘膜機能に対する酪酸菌懸濁液の効果
  • ケイカン エイヨウ シコウチュウ ノ コウレイ カンジャ チョウ ネンマク キ

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In patients who require total parenteral or enteral nutrition the intestinal lining may atrophy and the ability to absorb nutrients may be lost. To prevent atrophy of the small intestine, we administered a suspension of Clostridium butyricum to elderly patients receiving tube feeding, and then measured the activation of serum diamine oxidase and the number, form, water content, and bacteria content of stools, indicators of intestinal structure. We found a signficant increase in diamine oxidase activity and an improvement in stool condition: the number of stools per day decreased, form improved, and water content and the number of aerobic bacteria decreased significantly. These results indicate that in patients receiving long-term tube feeding, administration of Clostridium butyricum can restore condition to a near-normal state.

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