初発脳血栓のＭＲ画像　特に随伴所見と加齢，痴呆との関連

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書誌事項

タイトル別名
  • Brain MRI Findings in Patients with Initial Cerebral Thrombosis and the Relationship between Incidental Findings, Aging and Dementia.
  • ショハツ ノウ ケッセン ノ MR ガゾウ トクニ ズイハン ショケン ト カ
  • 特に随伴所見と加齢, 痴呆との関連
公開日
1994
資源種別
journal article
DOI
  • 10.3143/geriatrics.31.879
公開者
一般社団法人 日本老年医学会

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説明

To estimate the relationship between aging, dementia and changes observed on magnetic resonance imaging (MRI) seen in elderly patients with cerebral thrombosis, MRI findings in 103 patients with an initial stroke event (thrombosis group) were compared with those of 37 patients with hypertension/diabetes (high risk group) and 78 patients without those disorders (low risk group). In addition to the causative lesions in the thrombosis group, periventricular hyperintensities (PVH), spotty lesions (SL), silent infarctions (SI), ventricular dilatation (VD), and cortical atrophy (CA) were analyzed in these groups. Infarctions located in the internal capsule/corona radiata were the most frequent causative lesion. Compared to the low risk group, a high incidence of patchy/diffuse PVH, SI, and severe CA was seen in both the thrombosis group and the high risk group. Widespread PVH and multiple SL increased with age in the thrombosis group, while severe CA was seen in each group. SI and VD tended to increase after age 60, though they were not significant. Dementia, diagnosed in 40 out of 78 patients, increased with age. Multivariate analysis revealed the degree of the effects of MRI findings on dementia to be marked in PVH, brain atrophy, causative lesions, and SL, in that order. These results indicated that diffuse PVH and brain atrophy, developing with age, promoted dementia in the elderly with vascular lesions. Moreover, they suggested that a variety of silent brain lesions recognized on MRI other than infarction can affect symptoms in the elderly.

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