α‐Ａｍｙｌａｓｅ活性阻害Ｘ‐２物質の効果についての検討

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  • Studies on Effects of α-Amylase Inhibitor-X-2 Substance
  • アルファ Amylase カッセイ ソガイ X 2 ブッシツ ノ コウカ ニ

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It has been reported that dietary fibers like glucomannan was useful both in the treatment of diabetics and in the prevention of obesity. However, the literatures on the inhibitors of α-amylase were not comfirmed yet fully. To evaluate whether an α-amylase inhibitor-X-2 substance isolated from streptomyces fradiae could be benefit therapeutically in diabetics and prophylactically in obesity, firstly, we examined the effects of X-2 substance on glucoside hydrolases derived from both the small intestinal mucosa of pigs and the human pancreatic juice. Secondly, we would like to evaluate the optimal concentration of X-2 substance in vivo by normal and/or alloxan induced diabetic rats.<br>The results obtained were as follows:<br>1) X-2 substance showed the inhibitory effect on α-amylase markedly, which also had the weak inhibitory effect on sucrase.<br>2) 66, 000U/kg of X-2 substance reduced the level of blood glucose in alloxan induced diabetic rats significantly, and the level of serum insulin in normal rats with starch loading (2g/kg).<br>3) 180, 000U/kg of X-2 substance was necessary for sucrose loading (2g/kg) to obtain the same effect as starch loading on the reduction of blood glucose in alloxan induced diabetic rats and of serum insulin in normal rats.

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