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- 松下 哲
- 東京都老人医療センター
書誌事項
- タイトル別名
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- Longevity, Disease, and Duration of Disability.
- コウレイ シッカン ト カイゴ モンダイ ト テンボウ ジリツ キノウ ショウ
- 自立機能障害の生物学
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説明
Disability and the resulting lowered quality of life are serious issues accompanying increased longevity. Active life expectancy #(8) can be to used to distinguish the number of years without disability from the number with disability; increases were found in both in longevity #(9, 19). With the same rate of age-related new disability in the cohorts between 1970 and 1990, the total disability increased three fold #(11). In elderly patients I showed that 1) the duration of disability of those at a specific age at death (predeath) #(1) increased with age, and it decreased in those who remained without disability, 2) the cumulative number of days of disability for patients who died at a specific age (a convolution function of predeath and mortality) #(2), approached a normal distribution, which is consistent with the central limit theorem, 3) competing risk with chronic disease in a patient greatly affects the incidence and duration of disability, 4) using the central limit theorem we can predict that preventing dementia will retard premature rectangularization of the disability-free survival curve, and will thus reduce the total disability, 5) disability is an example of how variation and selection of chronic diseases (disease Darwinism) can alter population structure. Insights into the evolution of senescence # (14-21), pleiotropy, and slower rates of molecular evolution in the core than at the border #(26, 27), reveal that the central nervous system is relatively robust and conservative for pleiotropy and may senesce relatively slowly, which support a new way of thinking #(3, 4) about old age. To minimize disability, public knowledge and education about an ideal lifestyle and the evolution of senescence is essential.
収録刊行物
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- 日本老年医学会雑誌
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日本老年医学会雑誌 33 (12), 916-922, 1996
一般社団法人 日本老年医学会
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詳細情報 詳細情報について
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- CRID
- 1390282679999402112
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- NII論文ID
- 10013852395
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- NII書誌ID
- AN00199010
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- NDL書誌ID
- 4140867
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- ISSN
- 03009173
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- PubMed
- 9059050
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可