Relation of hypertension and glucose tolerance impairment in elderly people to the development of arteriosclerosis

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  • Isobe Takeshi
    Second Department of Internal Medicine, Sapporo Medical University, School of Medicine
  • Saitoh Shigeyuki
    Second Department of Internal Medicine, Sapporo Medical University, School of Medicine
  • Takagi Satoru
    Second Department of Internal Medicine, Sapporo Medical University, School of Medicine
  • Ohnishi Hirofumi
    Second Department of Internal Medicine, Sapporo Medical University, School of Medicine
  • Ohhata Junichi
    Second Department of Internal Medicine, Sapporo Medical University, School of Medicine
  • Takeuti Hiroshi
    Second Department of Internal Medicine, Sapporo Medical University, School of Medicine
  • Fujiwara Tadashi
    Second Department of Internal Medicine, Sapporo Medical University, School of Medicine
  • Akasaka Hirosi
    Second Department of Internal Medicine, Sapporo Medical University, School of Medicine
  • Shimamoto Kazuaki
    Second Department of Internal Medicine, Sapporo Medical University, School of Medicine

Bibliographic Information

Other Title
  • 老年者男性における高血圧と耐糖能異常の動脈硬化への影響
  • 老年者男性における高血圧と耐糖能異常の動脈硬化への影響 PWVを用いた検討--端野・壮瞥町研究
  • ロウネンシャ ダンセイ ニ オケル コウケツアツ ト タイトウノウ イジョウ ノ ドウミャク コウカ エ ノ エイキョウ PWV オ モチイタ ケントウ タンノ ソウベツチョウ ケンキュウ
  • PWVを用いた検討-端野・壮瞥町研究-
  • Investigation using pulse wave velocity

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Abstract

Hypertension and diabetes are risk factors for arteriosclerosis and have a synergistic effect on the progression of arteriosclerosis. The aim of this study was to determine the correlation between complications of hypertension and diabetes and arteriosclerosis as assessed by pulse wave velocity (PWV) in elderly subjects. The subjects of this study were 186 people aged 60 years or older (mean age: 68.8±5.8 years) who were scheduled to undergo health examinations. PWV, systolic blood pressure (SBP), diastolic blood pressure (DBP), body mass index (BMI), fasting blood sugar (FBS), total cholesterol (TC), triglyceride (TG) and HDL cholesterol (HDL) were measured in each subject. The patients were divided according to the American Diabetes Association (ADA) diagnostic criteria for diabetes based on fasting blood sugar level into the following three groups: a normal (NGT) group (FBS<110mg/dl), an impaired fasting glucose (IFG) group (110≤FBS<126mg/dl) and a diabetes mellitus (DM) group (FBS≥126mg/dl or receiving treatment for diabetes). Based on the JNC-VI and WHO/ISH diagnostic criteria, subjects who had a SBP of 140mmHg or higher or a DBP of 90mmHg or higher or who had been taking hypotensive drugs were assigned to the hypertension (HT) group, and the other subjects were assigned to the normotension (NT) group. PWV showed significant positive correlations with SBP and FBS (r=0.499 and r=0.300, respectively). The effects of hypertension on PWV were significantly higher in subjects with HT than in subjects with NT in all of the glucose tolerance groups (all p<0.01). Moreover, in the subjects with HT, PWV started to increase from the IFG stage, and PWV was significantly higher in the DM groups than in the NGT group (p<0.01). In multiple regression analysis using PWV as an objective variable, SBP and FBS were selected as significant explanatory variables. The results of this study indicate the need for stricter management of elderly people with slight glucose tolerance impairment and hypertension in order to prevent the occurrence of arteriosclerosis.

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