Eosinophilic Leukemia with Cyclic Eosinophilic Leukocytosis

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  • SADA Eiji
    The First Department of Internal Medicine, Faculty of Medicine, Ehime University
  • YANAGISAWA Kosuke
    The First Department of Internal Medicine, Faculty of Medicine, Ehime University
  • HASEGAWA Hitoshi
    The First Department of Internal Medicine, Faculty of Medicine, Ehime University
  • FUJITA Shigeru
    The First Department of Internal Medicine, Faculty of Medicine, Ehime University
  • KOBAYASHI Yuzuru
    The First Department of Internal Medicine, Faculty of Medicine, Ehime University
  • KONO Hidehisa
    Division of Internal Medicine, Uwajima City Hospital
  • KONDO Toshifumi
    Division of Internal Medicine, Uwajima City Hospital

Bibliographic Information

Other Title
  • 周期的に白血球数の変動を示した好酸球性白血病

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Description

A 36-year-old male was admitted to the Ehime University Hospital with anemia, eosinophilia and hepatosplenomegaly. Peripheral blood examination demonstrated severe anemia (Hb 7.1 g/dl), thrombocytopenia (Plt 6.8×104/μl) and increase of peripheral leukocytecounts (53,000/μl) with 32.0% of eosinophils which had lobulated nuclei, abnormal distribution of eosinophilic granules and a few vacuoles. The level of serum IgE was low (<5IU/ml), while that of serum vitamin B12 was elevated. A diagnosis of eosinophilic leukemia was made. He was noted to have spontaneous fluctuations in his eosinophil and total leukocyte counts. To analyze the mechanism of cyclic eosinophilic leukocytosis, we examined eosinophil colony stimulating activity of the serum and plasma of the patient. These examination showed that eosinophil colony-stimulating activity was not found in his serum and plasma, and cyclic eosinophilic leukocytosis was due to the hemopoietic stem cell disorder.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 33 (12), 1884-1889, 1992

    The Japanese Society of Hematology

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